the effects of unilateral varicose ovarian vein on antioxidant capacity and oocyte quality in rat ovary
نویسندگان
چکیده
objective(s): several researchers have reported the relationship between infertility in male and varicocele for so many years but the implication of varicocele in female patients is remains elusive. here, we aim to examine the effects of unilateral varicose ovarian vein on antioxidant capacity and oocyte quality of rat ovary after the experimental creation of varicocele in female rats. materials and methods: in this study, thirty adult female albino rats were divided into three equal groups: group 1 as the control group has 10 rats, group 2 as the sham group has 10 rats and they underwent a sham operation and finally group 3 has the varicocele group has 10 rats. antioxidant assays for superoxide dismutase, glutathioneperoxidase and catalase were performed using specific assay kits and gene expression for bax, bmp-15, hsp-27 and gdf-9 was done via real time pcr. results: the adverse effects of the experimentally induced varicocele were reported and recorded on the left ovary compared to the right sided ovary (no varicocele induction) in the varicocele group. real time pcr data shows that the expression of gdf-9, hsp-27 and bmp-15 genes were all significantly reduced at p≤0.05. conclusion: the results of this study show that reduced gene expression of bmp-15, gdf-9 and hsp-27, increased gene expression of bax and an imbalance between pro-oxidant/ antioxidant ratio are few of the several mechanisms by which varicocele may lead to infertility in female.
منابع مشابه
The effects of unilateral varicose ovarian vein on antioxidant capacity and oocyte quality in rat ovary
Objective(s): Several researchers have reported the relationship between infertility in male and varicocele for so many years but the implication of varicocele in female patients is remains elusive. Here, we aim to examine the effects of unilateral varicose ovarian vein on antioxidant capacity and oocyte quality of rat ovary after the experimental creation of varicocele in female rats. Material...
متن کاملThe effects of unilateral varicose ovarian vein on antioxidant capacity and oocyte quality in rat ovary
OBJECTIVES Several researchers have reported the relationship between infertility in male and varicocele for so many years but the implication of varicocele in female patients is remains elusive. Here, we aim to examine the effects of unilateral varicose ovarian vein on antioxidant capacity and oocyte quality of rat ovary after the experimental creation of varicocele in female rats. MATERIALS...
متن کاملThe effect of the ovarian varicose vein on the DNA methylation in the rat’s oocyte
Objective(s): We intended to determine whether the ovarian varicose which is one of the common etiologies of the pelvic congestion syndrome, has the ability to interfere with the DNA methylation reprogramming in the oocyte and thereby affect the oocyte quality or not. Materials and Methods: Varicose model was induced according to the Turner’s method in the rats. Briefly, a 20-gauge needle was p...
متن کاملThe effect of the ovarian varicose vein on the DNA methylation in the rat’s oocyte
Objectives We intended to determine whether the ovarian varicose which is one of the common etiologies of the pelvic congestion syndrome, has the ability to interfere with the DNA methylation reprogramming in the oocyte and thereby affect the oocyte quality or not. Materials and Methods Varicose model was induced according to the Turner's method in the rats. Briefly, a 20-gauge needle was pla...
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عنوان ژورنال:
iranian journal of basic medical sciencesجلد ۱۹، شماره ۸، صفحات ۸۶۳-۸۶۹
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